Withdrawal signs or symptoms occur in infants born to mothers who get barbiturates throughout the final trimester of pregnancy

Contraindicated (1)pentobarbital will lessen the extent or effect of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lower the level or impact of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will lessen the level or result of felodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

pentobarbital will minimize the level or impact of cortisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

Estradiol valerate/dienogest should not be applied for at least 28 days after discontinuation on the inducer because of possibility of lessened contraceptive efficacy.

Following stopping a CYP3A4 inducer, since the effects on the inducer drop, the fentanyl plasma focus will raise which could enhance or extend both the therapeutic and adverse effects.

pentobarbital will minimize the extent or effect of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.

pentobarbital will minimize the level or outcome of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. The efficacy of hormonal contraceptives might be lessened.

Reserve concomitant prescribing of these drugs in people for whom other treatment method possibilities are inadequate. Restrict dosages and durations to your bare minimum required. Watch carefully for indications of respiratory depression and sedation.

benzhydrocodone/acetaminophen and pentobarbital both boost sedation. Keep away from or Use Alternate Drug. Restrict use to clients for whom alternate treatment choices are inadequate

pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. get more info Coadministration of CYP3A4 inducers may minimize sufentanil amounts and efficacy, probably precipitating withdrawal syndrome in individuals who've developed Actual physical dependence to sufentanil. Discontinuation of concomitantly made use of CYP3A4 inducers may well enhance sufentanil plasma concentration.

pentobarbital will minimize the extent or effect of conjugated estrogens, vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will decrease the extent or impact of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.